San Francisco 49ers running back Christian McCaffrey suffered a knee injury that caused his night to end early in Sunday’s game against the Buffalo Bills.

In the second quarter, McCaffrey stepped awkwardly on a sweep to the left on a snow-slicked field. The All-Pro went down almost immediately for a 5-yard loss. He went to the sideline and was examined in the medical tent.

McCaffrey was initially ruled as questionable to return, but 49ers coach Kyle Shanahan told the NBC broadcast that he would miss the remainder of the game after halftime. 

The outing was McCaffrey’s fourth this season after the 2023 offensive player of the year missed the Niners’ first eight games with Achilles tendinitis. His 19-yard run in the first quarter was his longest of the season, and he had seven carries for 53 yards and two catches for 14 yards before getting hurt.

In four games, McCaffrey has totaled 50 carries for 202 yards, along with 15 catches for 146 yards. He has not scored a touchdown yet this season.

Jordan Mason took over as the 49ers’ featured back when McCaffrey left. 

The Associated Press contributed to this report.

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